Difference between revisions of "Lapuleucel-T (DN24-02)"
Andrewc072 (talk | contribs) (Created page with "==General information== Class/mechanism: Autologous cellular immunotherapy, designed to stimulate a response against HER2/Neu receptor. Autologous peripheral blood mononuclear...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: Autologous cellular immunotherapy, designed to stimulate a response against HER2/Neu receptor. Autologous peripheral blood mononuclear cells, which include antigen presenting cells (APCs), are obtained via leukapheresis. They are then activated ex vivo with a recombinant fusion protein.<ref>[http://clinicaltrials.gov/show/NCT01353222 ClinicalTrials.gov]</ref><ref>[http://www.dendreon.com/ | + | Class/mechanism: Autologous cellular immunotherapy, designed to stimulate a response against HER2/Neu receptor. Autologous peripheral blood mononuclear cells, which include antigen presenting cells (APCs), are obtained via leukapheresis. They are then activated ex vivo with a recombinant fusion protein.<ref>[http://clinicaltrials.gov/show/NCT01353222 ClinicalTrials.gov]</ref><ref>[http://www.dendreon.com/researchdevelopment/ACIproductcandidate/ DN24-02 manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
Revision as of 04:12, 4 July 2013
General information
Class/mechanism: Autologous cellular immunotherapy, designed to stimulate a response against HER2/Neu receptor. Autologous peripheral blood mononuclear cells, which include antigen presenting cells (APCs), are obtained via leukapheresis. They are then activated ex vivo with a recombinant fusion protein.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.