User talk:Binunair2002

LGL with treatment indications

Regimen 1

Methotrexate +/- Prednisone

• Methotrexate 7.5 to 10mg/m2 weekly po +
• Prednisone 1mg/kg po daily x one month then taper over 1 months.

stop if no response by 4 months, if response continue until progression

Supportive medications:

References

1. Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
2. Lamy T, Loughran TP.[1] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original artcle pubmed

Regimen 1

Cyclophosphamide +/- Prednisone

• [[ Cyclophosphamide 50-100 mg po daily

stop if no response by 4 months, if response continue for 6-12 months ,earlier if progression. Generous po fluid intake to prevent bladder toxicity

References

1. Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
2. Lamy T, Loughran TP.[2] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original article pubmed
3. Go RS, Li CY, Tefferi A, Phyliky RL(2001) Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood 98:483–5 link to original article pubmed