Irinotecan (Camptosar)

General information

Class/mechanism: Topoisomerase I inhibitor; derivative of camptothecin, which interferes with topoisomerase I's normal action of relieving torsional strain in DNA by creating reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I & DNA complex and interfere with ligation of these single-strand breaks. Failure to repair these breaks eventually leads to double-strand DNA damage, which disrupts cell proliferation and leads to cell death.
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Bone cancer
• Central nervous system (CNS) cancer
• Cervical cancer
• Colon cancer
• Esophageal cancer
• Non-small cell lung cancer
• Pancreatic cancer
• Penile cancer
• Small cell lung cancer
• Unknown primary

Patient drug information

• Irinotecan (Camptosar) patient drug information (Chemocare)
• Irinotecan (Camptosar) patient drug information (UpToDate)

History of changes in FDA indication

• 6/14/1996: Initial FDA approval for the treatment of patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following 5-FU-based therapy.
• 4/20/2000: Colon cancer indication revised:
  • Indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum.
  • Also indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.

Also known as

Synonyms
Campto Conc	Camptosar	Cloridrato DE Irinotecano	CPT-11	Elinatecan
Faultenocan	Irenax	Irinogen	Irinotecan Hydrochloride	Irinotecan Mayne
Irinotecan Rovi	Irinotel	Irnocam	Itoxaril	Linatecan
Satigene	Tecnotecan	Topotecin	Trinotecan	Winol