Difference between revisions of "Altretamine (Hexalen)"
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| − | Also known as Hexamethylmelamine. | + | Also known as Hexamethylmelamine or HMM. |
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==General information== | ==General information== | ||
| − | Class/mechanism: Alkylating-like, exact mechanism | + | Class/mechanism: Alkylating-like, exact mechanism unknown—can form covalent adducts with tissue macromolecules including DNA.<ref name="insert">[http://us.eisai.com/pdf_files/hexalen_pi.pdf Altretamine (Hexalen) package insert]</ref><ref>[[Media:Altretamine.pdf | Altretamine (Hexalen) package insert (locally hosted backup)]]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Ovarian cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/altretamine.aspx Altretamine (Hexalen) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/altretamine.asp Altretamine (Hexalen) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/altretamine-patient-drug-information Altretamine (Hexalen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/altretamine-patient-drug-information Altretamine (Hexalen) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/altretamine-patient-drug-information Altretamine (Hexalen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/altretamine-patient-drug-information Altretamine (Hexalen) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 01:59, 7 October 2012
Also known as Hexamethylmelamine or HMM.
General information
Class/mechanism: Alkylating-like, exact mechanism unknown—can form covalent adducts with tissue macromolecules including DNA.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Altretamine (Hexalen) patient drug information (Chemocare)[3]
- Altretamine (Hexalen) patient drug information (UpToDate)[4]