Difference between revisions of "Irinotecan (Camptosar)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
* 6/14/1996: Initial FDA approval for the treatment of patients with metastatic carcinoma of the [[Colon cancer | colon]] or [[Rectal cancer | rectum]] whose disease has recurred or progressed following [[Fluorouracil (5-FU) | 5-FU-based]] therapy. | * 6/14/1996: Initial FDA approval for the treatment of patients with metastatic carcinoma of the [[Colon cancer | colon]] or [[Rectal cancer | rectum]] whose disease has recurred or progressed following [[Fluorouracil (5-FU) | 5-FU-based]] therapy. | ||
− | * 4/20/2000: | + | * 4/20/2000: Indicated as a component of first-line therapy in combination with [[Fluorouracil (5-FU) | 5-fluorouracil]] and [[Folinic acid (Leucovorin) | leucovorin]] for patients with metastatic carcinoma of the [[Colon cancer | colon]] or [[Rectal cancer | rectum]]. |
− | + | * 4/20/2000: Also indicated for patients with metastatic carcinoma of the [[Colon cancer | colon]] or [[Rectal cancer | rectum]] whose disease has recurred or progressed following initial [[Fluorouracil (5-FU) | fluorouracil-based]] therapy. | |
− | * | ||
==Also known as== | ==Also known as== |
Revision as of 02:07, 30 November 2020
General information
Class/mechanism: Topoisomerase I inhibitor; derivative of camptothecin, which interferes with topoisomerase I's normal action of relieving torsional strain in DNA by creating reversible
single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase
I & DNA complex and interfere with ligation of these single-strand breaks. Failure to repair these breaks eventually leads to double-strand DNA damage, which disrupts cell proliferation and leads to cell death.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Adenocarcinoma of unknown primary
- Anaplastic glioma
- Cervical cancer
- Colon cancer
- Esophageal cancer
- Ewing sarcoma
- Gastric cancer
- Glioblastoma
- Neuroblastoma
- Non-small cell lung cancer
- Pancreatic cancer
- Penile cancer
- Rhabdomyosarcoma
- Small cell lung cancer
Patient drug information
- Irinotecan (Camptosar) patient drug information (Chemocare)[3]
- Irinotecan (Camptosar) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 6/14/1996: Initial FDA approval for the treatment of patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following 5-FU-based therapy.
- 4/20/2000: Indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum.
- 4/20/2000: Also indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.
Also known as
- Code names: Camptothecin-11, CPT-11, U-101440E
- Brand names: Axinotecan, Biotecan, Biskam, Campto, Campostar, Camptosar, Elinatecan, Faultenocan, Irenax, Irinogen, Irinomedac, Irinotel, Irinotesin, Irnocam, Itoxaril, Linatecan, Onivyde, Satigene, Tecnotecan, Tekamen, Toptecin, Trinotecan, Winol
References
- Drugs
- Intravenous medications
- Irritant
- Topoisomerase inhibitors
- Adenocarcinoma of unknown primary medications
- Anaplastic glioma medications
- Cervical cancer medications
- Colon cancer medications
- Esophageal cancer medications
- Ewing sarcoma medications
- Gastric cancer medications
- Glioblastoma medications
- Neuroblastoma medications
- Non-small cell lung cancer medications
- Pancreatic cancer medications
- Penile cancer medications
- Rhabdomyosarcoma medications
- Small cell lung cancer medications
- FDA approved in 1996
- WHO Essential Cancer Medicine